OPINION: Dr Ken Romeo 775-870-6942
“DNA double-strand breaks are rare, highly toxic, lesions requiring orchestrated and conserved machinery to prevent adverse consequences, such as cell death and cancer-causing genome structural mutations.”
Double strand breaks trigger the DNA damage response that directs a cell to repair the break or begin apoptosis.
There is a probability that double strand breaks are major drivers of intrinsic aging. A model was presented in Mol Cell. 2016 Sep 1;63(5):729-38. doi: 10.1016/j.molcel.2016.08.004., as to how double strand breaks could drive some of the basic mechanisms underlying age-related functional decline and death.
Dr. Ken Romeo is a Principal and Chief Clinical Data Coordinator for the Healthy Aging Research and Genomic Council (HARGC) in Reno, NV.
Though each article contained on this Blog is derived from published Clinical and Research data contained in various national and international databases with links provided,
NO ARTICLE OR CONCLUSION IS MEANT TO DIAGNOSE, TREAT, PREVENT OR CURE DISEASE.
CONSULT YOUR HEALTH PROFESSIONAL BEFORE MAKING ANY CHANGES TO YOUR HEALTH REGIMEN.
CONTACT: DrKenRomeo1@yahoo.com 775-870-6942