OPINION: Dr Ken Romeo 775-870-6942
Rutin, a quercetin glycoside is a member of the bioflavonoid family which is known to possess antioxidant properties. It can be purchased in tablet or cream form on the internet and in stores.
In a recent study, scientists aimed to confirm the anti‑aging effects of rutin on human dermal fibroblasts and human skin.
To examine the effects of rutin in vivo, rutin‑containing cream was applied to human skin. A double-blind clinical study was conducted in 40 subjects aged between 30-50 years and divided into control and experimental groups.
They examined the effects of rutin using a cell viability assay, senescence-associated-β-galactosidase assay, reverse transcription-quantitative polymerase chain reaction, and by measuring reactive oxygen species (ROS) scavenging activity in vitro.
The test material was applied for 4 weeks. After 2 and 4 weeks, dermal density, skin elasticity, the length and area of crow’s feet, and number of under-eye wrinkles following the application of either the control or the rutin-containing cream were analyzed.
Bottom line: Rutin increased the mRNA expression of collagen, type I, alpha 1 (COL1A1) and decreased the mRNA expression of matrix metallopeptidase 1 (MMP1) in HDFs.
The study verified that ROS scavenging activity was stimulated by rutin in a dose‑dependent manner and it identified that rutin exerted protective effects under conditions of oxidative stress.
Furthermore, rutin increased skin elasticity and decreased the length, area and number of wrinkles. The consequences of human aging are primarily visible on the skin, such as increased wrinkling, sagging and decreased elasticity. Overall, this study demonstrated the biological effects of rutin on ROS-induced skin aging.
According to WebMD, “RUTIN Side Effects & Safety: Rutin is LIKELY SAFE when taken by mouth in amounts found in fruits and vegetables. Rutin is POSSIBLY SAFE when taken by mouth appropriately in medicinal amounts for a short period of time. It can cause some side effects including headache, flushing, rashes, or stomach upset.”
The HARF does not endorse any specific Rutin products.
Yours in Health!
Dr. Ken Romeo
Dr. Ken Romeo is a Principal and Chief Clinical Data Coordinator for the Healthy Aging Research Foundation (HARF) in Reno, NV.
Though each article contained on this Blog is derived from published Clinical and Research data contained in various national and international databases with links provided,
NO ARTICLE OR CONCLUSION IS MEANT TO DIAGNOSE, TREAT, PREVENT OR CURE DISEASE.
CONSULT YOUR HEALTH PROFESSIONAL BEFORE MAKING ANY CHANGES TO YOUR HEALTH REGIMEN.
Source: Int J Mol Med. 2016 Jul;38(1):357-63. doi: 10.3892/ijmm.2016.2604. Epub 2016 May 24.