OPINION: Dr Ken Romeo 775-870-6942
Supercentenarians (aged 110 years old or more) are extremely rare in the world population. It is estimated that the number of living supercentenarians in the world is 47.
Details about their neuropathological information is limited. Based on previous studies, centenarians (aged 100-109 years old) exhibit several types of neuropathological changes, such as Alzheimer’s disease and Lewy body disease pathology, primary age-related increases in tau tangles and hippocampal sclerosis.
The most recent study gave analysis which, though inclusive, gives us insight into aging past 110. The pathologists found that the neuropathological alterations associated with aging were mild to moderate in the supercentenarian brain, suggesting that these individuals might have some neuroprotective factors against aging.
Can we equate the neuroprotective factors to genetics alone? Doubtful, but certainly genetics can’t be dismissed. Unfortunately, the study focused on brain structure and did not include any life-style data.
Future prospective studies and extensive molecular analyses are needed to determine the mechanisms of human longevity. And the molecular analyses need to be collated with lifestyle factors which eliminates the confounders.
Yours in Health!
Dr. Ken Romeo
Dr. Ken Romeo is a Principal and Chief Clinical Data Coordinator for the Healthy Aging Research Foundation (HARF) in Reno, NV.
Though each article contained on this Blog is derived from published Clinical and Research data contained in various national and international databases with links provided,
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