OPINION: Dr Ken Romeo 775-870-6942
This is the first report of the use of “18α-GA, a diet-derived compound as prolongevity and antiaggregation factor in the context of a multicellular organism.” The study abstract below has been copied word for word from the National Institutes of Public Health.
Translated into simple English the study means: Eat some “real” BLACK licorice for better health and anti aging including potentially slowing Alzheimer’s disease.
18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and
Alzheimer’s Disease Progression in Caenorhabditis elegans and Neuronal Cultures.
Proteasomes are constituents of the cellular proteolytic networks that maintain protein homeostasis through regulated proteolysis of normal and abnormal (in any way) proteins. Genetically mediated proteasome activation in multicellular organisms has been shown to promote longevity and to exert protein antiaggregation activity. In this study, we investigate whether compound-mediated proteasome activation is feasible in a multicellular organism and we dissect the effects of such approach in aging and Alzheimer’s disease (AD) progression.
Feeding of wild-type Caenorhabditis elegans with 18α-glycyrrhetinic acid (18α-GA; a previously shown proteasome activator in cell culture) results in enhanced levels of proteasome activities that lead to a skinhead-1- and proteasome activation-dependent life span extension. The elevated proteasome function confers lower paralysis rates in various AD nematode models accompanied by decreased Aβ deposits, thus ultimately decelerating the progression of AD phenotype. More importantly, similar positive results are also delivered when human and murine cells of nervous origin are subjected to 18α-GA treatment.
This is the first report of the use of 18α-GA, a diet-derived compound as prolongevity and antiaggregation factor in the context of a multicellular organism.
Our results suggest that proteasome activation with downstream positive outcomes on aging and AD, an aggregation-related disease, is feasible in a nongenetic manipulation manner in a multicellular organism. Moreover, they unveil the need for identification of antiagingand antiamyloidogenic compounds among the nutrients found in our normal diet. Antioxid. Redox Signal. 00, 000-000.”
The HARF does not endorse any specific licorice product.
Source: Antioxid Redox Signal. 2016 Mar 30
Yours in Health!
Dr. Ken Romeo
Dr. Ken Romeo is a Principal and Chief Clinical Data Coordinator for the Healthy Aging Research Foundation in Reno, NV.
Though each article contained on this Blog is derived from published Clinical and Research data contained in various national and international databases with links provided,
NO ARTICLE OR CONCLUSION IS MEANT TO DIAGNOSE, TREAT, PREVENT OR CURE DISEASE.
CONSULT YOUR HEALTH PROFESSIONAL BEFORE MAKING ANY CHANGES TO YOUR HEALTH REGIMEN.