OPINION: Dr. Ken Romeo 775-870-6942
Our bodies have evolved at the subcellular level to not only sense but fight DNA damage. What’s more, our bodies respond in such a way as to repair DNA damage and/or kill the compromised cell if it is damaged too extensively – this process is accomplished through microRNAs.
MicroRNAs play a critical role in the bodies response to DNA damage and the good news is that science is now able to analyze microRNA pathways.
But what, if anything, can we do to help the microRNAs perform their life saving tasks?
Dietary intervention is a potential solution. Foods that contain epigallocatechin-3-gallate like green tea, apple skin, plums, onions, hazelnuts and pecans could help. Also curcumin and resveratrol contain properties that can boost microRNA levels.
The problem is that when food or tea are taken orally in normal amounts the bioavailability of epigallocatechin-3-gallate is small. A person would have to drink between 8-16 cups of green tea daily to have any effect. Drinking this amount of green tea could cause mild side effects such as nausea or heartburn.
For what it’s worth, epigallocatechin-3-gallate blood levels peak in approximately 1.7 hours and are then excreted in the urine over a period of 3-15 hours.
The best bet to help microRNAs do their job is probably nutraceutical supplementation with green tea extract, curcumin and/or resveratrol. Also, some specific fatty acids affect microRNA.
Specific pathways, such as fatty acids biosynthesis/metabolism, extracellular matrix-receptor interaction and signaling regulating the pluripotency of stem cells (an immature stem cell capable of giving rise to several different types of cells), appear to be targeted by most microRNAs.
Since DNA damage and DNA repair are strongly related to aging, anti-aging and carcinogenesis, supplementation with nutraceuticals and foods that feed microRNA may be a necessary component to a solid anti-aging and chemopreventive program.
Yours in Health!
Dr. Ken Romeo
Dr. Ken Romeo is a Principal and Chief Clinical Data Coordinator for the Healthy Aging Research Yours in Health!
Foundation (HARF) in Reno, NV.
Though each article contained on this Blog is derived from published Clinical and Research data contained in various national and international databases with links provided,
NO ARTICLE OR CONCLUSION IS MEANT TO DIAGNOSE, TREAT, PREVENT OR CURE DISEASE.
CONSULT YOUR HEALTH PROFESSIONAL BEFORE MAKING ANY CHANGES TO YOUR HEALTH REGIMEN.
Contact: DrKenRomeo1@gmail.com (Reno, NV)